Assay Detail
Binding
CHEMBL670095
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Inhibition of [3H]YM-09151-2 binding to bovine retina membrane Dopamine receptor D2, low affinity site
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N-n-Propyl-substituted 3-(dimethylphenyl)piperidines display novel discriminative properties between dopamine receptor subtypes: synthesis and receptor binding studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 4.98 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 5.82 |
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 5.59 |
| CHEMBL341825 | — | — | 1 | 5.11 |
| CHEMBL72630 | — | — | 1 | 5.09 |
| CHEMBL144114 | — | — | 1 | 5.03 |
| CHEMBL7549 | PRECLAMOL | 2.0 | 1 | 4.92 |
| CHEMBL144019 | — | — | 1 | 4.80 |
| CHEMBL144302 | — | — | 1 | 4.77 |
| CHEMBL356746 | — | — | 1 | 4.72 |
| CHEMBL144501 | — | — | 1 | 4.64 |
| CHEMBL342345 | — | — | 1 | 4.62 |
| CHEMBL280491 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59 | DOPAMINE | Ki | = | 1520.0 | nM | 5.82 |
| CHEMBL240773 | QUINPIROLE | Ki | = | 2580.0 | nM | 5.59 |
| CHEMBL341825 | — | Ki | = | 7800.0 | nM | 5.11 |
| CHEMBL72630 | — | Ki | = | 8200.0 | nM | 5.09 |
| CHEMBL144114 | — | Ki | = | 9300.0 | nM | 5.03 |
| CHEMBL7549 | PRECLAMOL | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL144019 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL144302 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL356746 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL144501 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL342345 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL280491 | — | Ki | = | 25000.0 | nM | 4.60 |