Compound Detail
CHEMBL144019
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Basic Information
| ChEMBL ID | CHEMBL144019 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | TXQGNZXKUWJMKW-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
189.3
MW (Da)
2.77
ALogP
1
HBA
1
HBD
12.0
PSA (Ų)
0.72
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 7.37
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(2) dopamine receptor CHEMBL3998 | Ki | 7.37 | 6.085 | 43.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(2) dopamine receptor | Ki | = | 43.0 | nM | 7.37 | Inhibition of [3H]YM-09151-2 binding to bovine retina membrane Dopamine receptor... | 9836610 |
| D(2) dopamine receptor | Ki | = | 16000.0 | nM | 4.8 | Inhibition of [3H]YM-09151-2 binding to bovine retina membrane Dopamine receptor... | 9836610 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9836610 | 10.1021/jm9708700 | D(2) dopamine receptor | 3 |
| 9836610 | 10.1021/jm9708700 | D(1A) dopamine receptor | 1 |
Data from ChEMBL 36 via Core Engine