Assay Detail
Binding
CHEMBL670125
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In vitro ability to displace Dopamine D2 receptor binding to rat striatal membranes in competition experiments against 3H-spiperone, expressed as Ki
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The synthesis and evaluation of the major metabolites of mazapertine
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.18 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10085 | MAZAPERTINE | 2.0 | 1 | 8.66 |
| CHEMBL58053 | — | — | 1 | 8.06 |
| CHEMBL58517 | — | — | 1 | 8.05 |
| CHEMBL61096 | — | — | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10085 | MAZAPERTINE | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL58053 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL58517 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL61096 | — | Ki | = | 11.0 | nM | 7.96 |