Assay Detail
Binding
CHEMBL670244
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Binding affinity to rat Dopamine receptor D2 expressed in CHO cells was determined using [125 I ] iodosulpride as radioligand
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1-aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.63 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.32 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.28 |
| CHEMBL26929 | — | — | 1 | 7.75 |
| CHEMBL322275 | — | — | 1 | 6.96 |
| CHEMBL444590 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL56 | 8-OH-DPAT | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL26929 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL322275 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL444590 | — | IC50 | = | 140.0 | nM | 6.85 |