Assay Detail
Functional
CHEMBL670410
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Agonistic activity towards dopamine D2 receptor using radioligand [3H]quinpirole in rat striatal membranes
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 8.01 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64553 | — | — | 1 | 9.80 |
| CHEMBL300571 | — | — | 1 | 9.46 |
| CHEMBL99913 | — | — | 1 | 8.80 |
| CHEMBL102490 | — | — | 1 | 8.59 |
| CHEMBL64508 | — | — | 1 | 8.44 |
| CHEMBL99849 | — | — | 1 | 8.36 |
| CHEMBL88365 | — | — | 1 | 8.26 |
| CHEMBL323118 | — | — | 1 | 8.10 |
| CHEMBL101285 | — | — | 1 | 8.02 |
| CHEMBL101032 | — | — | 1 | 7.79 |
| CHEMBL101910 | — | — | 1 | 7.71 |
| CHEMBL100952 | — | — | 1 | 7.19 |
| CHEMBL103951 | — | — | 1 | 7.17 |
| CHEMBL100461 | — | — | 1 | 6.95 |
| CHEMBL103900 | — | — | 1 | 6.92 |
| CHEMBL319816 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64553 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL300571 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL99913 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL102490 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL64508 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL99849 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL88365 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL323118 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL101285 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL101032 | — | Ki | = | 16.2 | nM | 7.79 |
| CHEMBL101910 | — | Ki | = | 19.7 | nM | 7.71 |
| CHEMBL100952 | — | Ki | = | 64.7 | nM | 7.19 |
| CHEMBL103951 | — | Ki | = | 68.4 | nM | 7.17 |
| CHEMBL100461 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL103900 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL319816 | — | Ki | = | 237.0 | nM | 6.62 |