Assay Detail
Binding
CHEMBL670415
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Ability to displace [3H]spiperone from D2 dopamine receptor isolated from the striata of male Wistar rats
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
N-(2-pyrrolidinylmethyl)benzoxazine-8-carboxamides exhibiting high affinities for All of D2, 5-HT1 A, and 5-HT2 receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 7.54 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.82 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.74 |
| CHEMBL21971 | — | — | 1 | 8.44 |
| CHEMBL22772 | — | — | 1 | 8.42 |
| CHEMBL278151 | — | — | 1 | 8.38 |
| CHEMBL21802 | — | — | 1 | 8.19 |
| CHEMBL21819 | — | — | 1 | 7.80 |
| CHEMBL21318 | — | — | 1 | 7.77 |
| CHEMBL22306 | — | — | 1 | 7.72 |
| CHEMBL279937 | — | — | 1 | 7.24 |
| CHEMBL278838 | — | — | 1 | 7.08 |
| CHEMBL21940 | — | — | 1 | 7.04 |
| CHEMBL280912 | — | — | 1 | 6.75 |
| CHEMBL22468 | — | — | 1 | 6.68 |
| CHEMBL22835 | — | — | 1 | 6.57 |
| CHEMBL21386 | — | — | 1 | 6.51 |
| CHEMBL281363 | — | — | 1 | 6.10 |
| CHEMBL279292 | — | — | 1 | - |
| CHEMBL21680 | — | — | 1 | - |
| CHEMBL21403 | — | — | 1 | - |
| CHEMBL418374 | — | — | 1 | - |
| CHEMBL22154 | — | — | 1 | - |
| CHEMBL418560 | — | — | 1 | - |
| CHEMBL282935 | — | — | 1 | - |
| CHEMBL279698 | — | — | 1 | - |
| CHEMBL22469 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL85 | RISPERIDONE | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL21971 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL22772 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL278151 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL21802 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL21819 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL21318 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL22306 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL279937 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL278838 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL21940 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL280912 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL22468 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL22835 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL21386 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL281363 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL279292 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL21680 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL21403 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL418374 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL22154 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL418560 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL282935 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL279698 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL22469 | — | Ki | > | 1000.0 | nM | - |