Assay Detail
Binding
CHEMBL670416
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Compound was evaluated for its ability to displace [3H]spiperone from D2 dopamine receptor isolated from the striata of male Wistar rats
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-(2-pyrrolidinylmethyl)benzoxazine-8-carboxamides exhibiting high affinities for All of D2, 5-HT1 A, and 5-HT2 receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.63 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283528 | — | — | 1 | 7.92 |
| CHEMBL22857 | — | — | 1 | 7.29 |
| CHEMBL278762 | — | — | 1 | 6.64 |
| CHEMBL22465 | — | — | 1 | 6.57 |
| CHEMBL279729 | — | — | 1 | 6.20 |
| CHEMBL280879 | — | — | 1 | 6.17 |
| CHEMBL22777 | — | — | 1 | 6.16 |
| CHEMBL284027 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283528 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL22857 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL278762 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL22465 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL279729 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL280879 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL22777 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL284027 | — | Ki | = | 750.0 | nM | 6.12 |