Assay Detail
Binding
CHEMBL670447
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In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
(+/-)-7-chloro-8-hydroxy-1-(4'-[125I]iodophenyl)-3-methyl-2,3,4,5- tetrahydro-1H-3-benzazepine: a potential CNS D-1 dopamine receptor imaging agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.03 | 9.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | — | 1 | 9.41 |
| CHEMBL34170 | — | — | 1 | 8.77 |
| CHEMBL290118 | — | — | 1 | 7.87 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 6.05 |
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL34170 | — | Ki | = | 1.71 | nM | 8.77 |
| CHEMBL290118 | — | Ki | = | 13.4 | nM | 7.87 |
| CHEMBL53 | APOMORPHINE | Ki | = | 888.0 | nM | 6.05 |
| CHEMBL267930 | SPIPERONE | Ki | > | 3000.0 | nM | - |