Assay Detail
Binding
CHEMBL670522
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards Dopamine receptor D2 binding site using [3H]spiroperidol.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.43 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.12 |
| CHEMBL59940 | — | — | 1 | 7.82 |
| CHEMBL61747 | — | — | 1 | 7.70 |
| CHEMBL59335 | — | — | 1 | 7.35 |
| CHEMBL64344 | — | — | 1 | 7.29 |
| CHEMBL60267 | — | — | 1 | 6.80 |
| CHEMBL279586 | — | — | 1 | 6.75 |
| CHEMBL42228 | — | — | 1 | 6.19 |
| CHEMBL61479 | SIRAMESINE | 2.0 | 1 | 6.10 |
| CHEMBL59464 | — | — | 1 | 5.89 |
| CHEMBL416506 | — | — | 1 | 5.52 |
| CHEMBL303336 | — | — | 1 | 5.43 |
| CHEMBL61539 | — | — | 1 | 5.38 |
| CHEMBL62994 | — | — | 1 | 5.10 |
| CHEMBL60859 | BMY-14802 | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL59940 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL61747 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL59335 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL64344 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL60267 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL279586 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL42228 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL61479 | SIRAMESINE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL59464 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL416506 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL303336 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL61539 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL62994 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL60859 | BMY-14802 | IC50 | = | 8400.0 | nM | 5.08 |