Assay Detail
Functional
CHEMBL670542
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Effective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D2L by mitogenesis assay (intrinsic activity)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO-L6 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Thiazoloindans and thiazolobenzopyrans: a novel class of orally active central dopamine (partial) agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.99 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325710 | — | — | 1 | 8.24 |
| CHEMBL118636 | — | — | 1 | 7.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325710 | — | EC50 | = | 5.7 | nM | 8.24 |
| CHEMBL118636 | — | EC50 | = | 18.7 | nM | 7.73 |