Assay Detail
Binding
CHEMBL670547
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Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2 low affinity without GTP and sodium
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.90 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL87192 | — | — | 1 | 8.72 |
| CHEMBL327782 | — | — | 1 | 8.59 |
| CHEMBL329398 | — | — | 1 | 8.57 |
| CHEMBL89037 | — | — | 1 | 8.35 |
| CHEMBL314174 | — | — | 1 | 8.33 |
| CHEMBL86504 | — | — | 1 | 7.94 |
| CHEMBL59752 | — | — | 1 | 7.94 |
| CHEMBL87067 | — | — | 1 | 7.58 |
| CHEMBL87137 | — | — | 1 | 7.45 |
| CHEMBL64283 | — | — | 1 | 7.41 |
| CHEMBL64508 | — | — | 1 | 7.00 |
| CHEMBL89420 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL87192 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL327782 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL329398 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL89037 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL314174 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL86504 | — | Ki | = | 11.6 | nM | 7.94 |
| CHEMBL59752 | — | Ki | = | 11.4 | nM | 7.94 |
| CHEMBL87067 | — | Ki | = | 26.6 | nM | 7.58 |
| CHEMBL87137 | — | Ki | = | 35.9 | nM | 7.45 |
| CHEMBL64283 | — | Ki | = | 39.3 | nM | 7.41 |
| CHEMBL64508 | — | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL89420 | — | Ki | = | 128.0 | nM | 6.89 |