Assay Detail
Binding
CHEMBL670670
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity measured on dopamine receptor D2 using [3H]spiroperidol as radioligand.
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
High affinity and selectivity on 5-HT1A receptor of 1-aryl-4-[1-tetralin)alkyl]piperazines. 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.04 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6066838 | — | — | 1 | 9.30 |
| CHEMBL174703 | — | — | 1 | 8.11 |
| CHEMBL366459 | — | — | 1 | 7.97 |
| CHEMBL173190 | — | — | 1 | 7.95 |
| CHEMBL174300 | — | — | 1 | 7.90 |
| CHEMBL28209 | — | — | 1 | 7.81 |
| CHEMBL172161 | — | — | 1 | 7.76 |
| CHEMBL26929 | — | — | 1 | 7.70 |
| CHEMBL174083 | — | — | 1 | 7.62 |
| CHEMBL368477 | — | — | 1 | 7.61 |
| CHEMBL172601 | — | — | 1 | 7.55 |
| CHEMBL172556 | — | — | 1 | 7.30 |
| CHEMBL424125 | — | — | 1 | 7.29 |
| CHEMBL172363 | — | — | 1 | 7.29 |
| CHEMBL367435 | — | — | 1 | 7.04 |
| CHEMBL322275 | — | — | 1 | 7.01 |
| CHEMBL175300 | — | — | 1 | 6.92 |
| CHEMBL140406 | — | — | 1 | 6.82 |
| CHEMBL444590 | — | — | 1 | 6.75 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 6.65 |
| CHEMBL148055 | — | — | 1 | 6.52 |
| CHEMBL171181 | — | — | 1 | 6.48 |
| CHEMBL176819 | — | — | 1 | 6.33 |
| CHEMBL108241 | — | — | 1 | 6.21 |
| CHEMBL171974 | — | — | 1 | 6.19 |
| CHEMBL277302 | — | — | 1 | 6.11 |
| CHEMBL143110 | — | — | 1 | 6.11 |
| CHEMBL433972 | — | — | 1 | 5.89 |
| CHEMBL367723 | — | — | 1 | 5.88 |
| CHEMBL174554 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6066838 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL174703 | — | IC50 | = | 7.83 | nM | 8.11 |
| CHEMBL366459 | — | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL173190 | — | IC50 | = | 11.3 | nM | 7.95 |
| CHEMBL174300 | — | IC50 | = | 12.7 | nM | 7.90 |
| CHEMBL28209 | — | IC50 | = | 15.4 | nM | 7.81 |
| CHEMBL172161 | — | IC50 | = | 17.4 | nM | 7.76 |
| CHEMBL26929 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL174083 | — | IC50 | = | 24.1 | nM | 7.62 |
| CHEMBL368477 | — | IC50 | = | 24.7 | nM | 7.61 |
| CHEMBL172601 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL172556 | — | IC50 | = | 50.2 | nM | 7.30 |
| CHEMBL424125 | — | IC50 | = | 51.5 | nM | 7.29 |
| CHEMBL172363 | — | IC50 | = | 50.9 | nM | 7.29 |
| CHEMBL367435 | — | IC50 | = | 90.6 | nM | 7.04 |
| CHEMBL322275 | — | IC50 | = | 96.7 | nM | 7.01 |
| CHEMBL175300 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL140406 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL444590 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL49 | BUSPIRONE | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL148055 | — | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL171181 | — | IC50 | = | 328.0 | nM | 6.48 |
| CHEMBL176819 | — | IC50 | = | 472.0 | nM | 6.33 |
| CHEMBL108241 | — | IC50 | = | 618.0 | nM | 6.21 |
| CHEMBL171974 | — | IC50 | = | 644.0 | nM | 6.19 |
| CHEMBL277302 | — | IC50 | = | 778.0 | nM | 6.11 |
| CHEMBL143110 | — | IC50 | = | 777.0 | nM | 6.11 |
| CHEMBL433972 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL367723 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL174554 | — | IC50 | = | 5920.0 | nM | 5.23 |