Assay Detail
Binding
CHEMBL670672
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In vitro binding affinity for Dopamine D2 receptor of rat using [3H]YM-09151 as radioligand
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacological evaluation of 1-[(1,2-diphenyl-1H-4-imidazolyl)methyl]-4-phenylpiperazines with clozapine-like mixed activities at dopamine D(2), serotonin, and GABA(A) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.50 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8809 | RACLOPRIDE | 2.0 | 1 | 8.47 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.76 |
| CHEMBL143744 | — | — | 1 | 7.46 |
| CHEMBL358316 | — | — | 1 | 7.15 |
| CHEMBL356068 | — | — | 1 | 7.04 |
| CHEMBL143372 | — | — | 1 | 6.92 |
| CHEMBL342119 | — | — | 1 | 6.87 |
| CHEMBL143218 | — | — | 1 | 6.78 |
| CHEMBL344202 | — | — | 1 | 6.78 |
| CHEMBL142147 | — | — | 1 | 6.57 |
| CHEMBL344084 | — | — | 1 | 6.53 |
| CHEMBL356993 | — | — | 1 | 6.39 |
| CHEMBL142825 | — | — | 1 | 6.00 |
| CHEMBL142309 | — | — | 1 | 5.99 |
| CHEMBL141077 | — | — | 1 | 5.89 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 5.68 |
| CHEMBL141824 | — | — | 1 | 5.67 |
| CHEMBL344796 | — | — | 1 | 5.56 |
| CHEMBL356116 | — | — | 1 | 5.31 |
| CHEMBL341743 | — | — | 1 | 5.24 |
| CHEMBL344995 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8809 | RACLOPRIDE | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL54 | HALOPERIDOL | IC50 | = | 17.5 | nM | 7.76 |
| CHEMBL143744 | — | IC50 | = | 34.7 | nM | 7.46 |
| CHEMBL358316 | — | IC50 | = | 70.3 | nM | 7.15 |
| CHEMBL356068 | — | IC50 | = | 91.8 | nM | 7.04 |
| CHEMBL143372 | — | IC50 | = | 120.2 | nM | 6.92 |
| CHEMBL342119 | — | IC50 | = | 135.5 | nM | 6.87 |
| CHEMBL143218 | — | IC50 | = | 167.2 | nM | 6.78 |
| CHEMBL344202 | — | IC50 | = | 167.5 | nM | 6.78 |
| CHEMBL142147 | — | IC50 | = | 267.5 | nM | 6.57 |
| CHEMBL344084 | — | IC50 | = | 295.5 | nM | 6.53 |
| CHEMBL356993 | — | IC50 | = | 408.5 | nM | 6.39 |
| CHEMBL142825 | — | IC50 | = | 1007.5 | nM | 6.00 |
| CHEMBL142309 | — | IC50 | = | 1017.0 | nM | 5.99 |
| CHEMBL141077 | — | IC50 | = | 1285.5 | nM | 5.89 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 2108.0 | nM | 5.68 |
| CHEMBL141824 | — | IC50 | = | 2135.5 | nM | 5.67 |
| CHEMBL344796 | — | IC50 | = | 2744.0 | nM | 5.56 |
| CHEMBL356116 | — | IC50 | = | 4908.0 | nM | 5.31 |
| CHEMBL341743 | — | IC50 | = | 5796.0 | nM | 5.24 |
| CHEMBL344995 | — | IC50 | > | 10000.0 | nM | - |