Assay Detail
Binding
CHEMBL670674
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In vitro binding affinity against Dopamine receptor D2 like from rat caudate membrane using [3H]-spiperone as radioligand
39
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Substituted hexahydrobenzo[f]thieno[c]quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 39 | 6.03 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL542351 | — | — | 1 | 7.29 |
| CHEMBL41238 | — | — | 1 | 7.00 |
| CHEMBL290842 | — | — | 1 | 6.84 |
| CHEMBL44414 | — | — | 1 | 6.84 |
| CHEMBL40667 | — | — | 1 | 6.82 |
| CHEMBL41132 | — | — | 1 | 6.69 |
| CHEMBL2114440 | — | — | 1 | 6.62 |
| CHEMBL39266 | — | — | 1 | 6.52 |
| CHEMBL288536 | — | — | 1 | 6.47 |
| CHEMBL2114444 | — | — | 1 | 6.46 |
| CHEMBL289867 | — | — | 1 | 6.35 |
| CHEMBL289927 | — | — | 1 | 6.27 |
| CHEMBL287931 | — | — | 1 | 6.25 |
| CHEMBL2115377 | — | — | 2 | 6.19 |
| CHEMBL28338 | A-86929 | -1.0 | 1 | 6.10 |
| CHEMBL291100 | — | — | 1 | 6.04 |
| CHEMBL2115372 | — | — | 2 | 6.01 |
| CHEMBL554571 | — | — | 1 | 5.99 |
| CHEMBL40950 | — | — | 1 | 5.89 |
| CHEMBL417164 | — | — | 1 | 5.88 |
| CHEMBL2114441 | — | — | 1 | 5.86 |
| CHEMBL25856 | DIHYDREXIDINE | 2.0 | 1 | 5.85 |
| CHEMBL2115374 | — | — | 2 | 5.85 |
| CHEMBL41196 | — | — | 1 | 5.82 |
| CHEMBL446350 | — | — | 1 | 5.76 |
| CHEMBL291143 | — | — | 1 | 5.75 |
| CHEMBL41809 | — | — | 1 | 5.75 |
| CHEMBL38757 | — | — | 1 | 5.68 |
| CHEMBL43514 | — | — | 1 | 5.59 |
| CHEMBL288846 | — | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL542351 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL41238 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL290842 | — | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL44414 | — | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL40667 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL41132 | — | Ki | = | 205.0 | nM | 6.69 |
| CHEMBL2114440 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL39266 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL288536 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL2114444 | — | Ki | = | 345.0 | nM | 6.46 |
| CHEMBL289867 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL289927 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL287931 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL2115377 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL28338 | A-86929 | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL291100 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL2115372 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL554571 | — | Ki | = | 1030.0 | nM | 5.99 |
| CHEMBL40950 | — | Ki | = | 1290.0 | nM | 5.89 |
| CHEMBL417164 | — | Ki | = | 1320.0 | nM | 5.88 |
| CHEMBL2114441 | — | Ki | = | 1380.0 | nM | 5.86 |
| CHEMBL25856 | DIHYDREXIDINE | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL2115374 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL41196 | — | Ki | = | 1530.0 | nM | 5.82 |
| CHEMBL446350 | — | Ki | = | 1720.0 | nM | 5.76 |
| CHEMBL41809 | — | Ki | = | 1760.0 | nM | 5.75 |
| CHEMBL291143 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL38757 | — | Ki | = | 2090.0 | nM | 5.68 |
| CHEMBL288846 | — | Ki | = | 2560.0 | nM | 5.59 |
| CHEMBL43514 | — | Ki | = | 2590.0 | nM | 5.59 |
| CHEMBL542593 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL24077 | (R)-SKF-38393 | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL290149 | — | Ki | = | 3110.0 | nM | 5.51 |
| CHEMBL2115373 | — | Ki | = | 3260.0 | nM | 5.49 |
| CHEMBL2115373 | — | Ki | = | 4490.0 | nM | 5.35 |
| CHEMBL2115372 | — | Ki | = | 4790.0 | nM | 5.32 |
| CHEMBL2115374 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL2115377 | — | Ki | = | 5450.0 | nM | 5.26 |
| CHEMBL416435 | — | Ki | > | 10000.0 | nM | - |