Assay Detail
Binding
CHEMBL670969
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Binding affinity against dopamine (D2) receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and molecular modeling of 1-phenyl-1,2,3,4-tetrahydroisoquinolines and related 5,6,8,9-tetrahydro-13bH-dibenzo[a,h]quinolizines as D1 dopamine antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.86 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL60706 | — | — | 1 | 6.54 |
| CHEMBL135318 | — | — | 1 | 6.53 |
| CHEMBL299056 | — | — | 1 | 6.28 |
| CHEMBL62 | SCH-23390 | — | 1 | 6.17 |
| CHEMBL334350 | — | — | 1 | 5.88 |
| CHEMBL300778 | — | — | 1 | 5.72 |
| CHEMBL57988 | — | — | 1 | 5.44 |
| CHEMBL446396 | — | — | 1 | 5.43 |
| CHEMBL293158 | — | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL60706 | — | Ki | = | 288.4 | nM | 6.54 |
| CHEMBL135318 | — | Ki | = | 295.12 | nM | 6.53 |
| CHEMBL299056 | — | Ki | = | 524.81 | nM | 6.28 |
| CHEMBL62 | SCH-23390 | Ki | = | 676.08 | nM | 6.17 |
| CHEMBL334350 | — | Ki | = | 1318.26 | nM | 5.88 |
| CHEMBL300778 | — | Ki | = | 1905.46 | nM | 5.72 |
| CHEMBL57988 | — | Ki | = | 3630.78 | nM | 5.44 |
| CHEMBL446396 | — | Ki | = | 3715.35 | nM | 5.43 |
| CHEMBL293158 | — | Ki | = | 19498.45 | nM | 4.71 |