Assay Detail
Binding
CHEMBL670970
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity against Dopamine receptor D2
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Conformationally constrained butyrophenones with affinity for dopamine (D(1), D(2), D(4)) and serotonin (5-HT(2A), 5-HT(2B), 5-HT(2C)) receptors: synthesis of aminomethylbenzo[b]furanones and their evaluation as antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.10 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.48 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.09 |
| CHEMBL143027 | — | — | 1 | 8.02 |
| CHEMBL143022 | — | — | 1 | 7.02 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.58 |
| CHEMBL142668 | — | — | 1 | 6.39 |
| CHEMBL357517 | — | — | 1 | 5.14 |
| CHEMBL358895 | — | — | 1 | - |
| CHEMBL142316 | — | — | 1 | - |
| CHEMBL143937 | — | — | 1 | - |
| CHEMBL141600 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 3.311 | nM | 8.48 |
| CHEMBL85 | RISPERIDONE | Ki | = | 8.128 | nM | 8.09 |
| CHEMBL143027 | — | Ki | = | 9.55 | nM | 8.02 |
| CHEMBL143022 | — | Ki | = | 95.5 | nM | 7.02 |
| CHEMBL42 | CLOZAPINE | Ki | = | 263.03 | nM | 6.58 |
| CHEMBL142668 | — | Ki | = | 407.38 | nM | 6.39 |
| CHEMBL357517 | — | Ki | = | 7244.36 | nM | 5.14 |
| CHEMBL358895 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL142316 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL143937 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL141600 | — | Ki | < | 10000.0 | nM | - |