Assay Detail
Binding
CHEMBL670971
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Compound was measured for the inhibition of [3H]spiperone binding to striatal membrane Dopamine receptor D2
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Butyrophenone analogues in the carbazole series: synthesis and determination of affinities at D2 and 5-HT2A receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.79 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.48 |
| CHEMBL333174 | — | — | 1 | 6.85 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.58 |
| CHEMBL120903 | — | — | 1 | 6.25 |
| CHEMBL121744 | — | — | 1 | 5.81 |
| CHEMBL327038 | — | — | 1 | - |
| CHEMBL118947 | — | — | 1 | - |
| CHEMBL118477 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 3.311 | nM | 8.48 |
| CHEMBL333174 | — | Ki | = | 141.25 | nM | 6.85 |
| CHEMBL42 | CLOZAPINE | Ki | = | 263.03 | nM | 6.58 |
| CHEMBL120903 | — | Ki | = | 562.34 | nM | 6.25 |
| CHEMBL121744 | — | Ki | = | 1548.82 | nM | 5.81 |
| CHEMBL327038 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL118947 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL118477 | — | Ki | < | 10000.0 | nM | - |