Assay Detail
Binding
CHEMBL670973
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity at native Dopamine receptor D2 in rat striatum by [3H]spiperone displacement.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and biological activity of prazosin-related antagonists. Role of the piperazine and furan units of prazosin on the selectivity for alpha1-adrenoreceptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.22 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13647 | BMY-7378 | — | 1 | 7.32 |
| CHEMBL341665 | — | — | 1 | 5.71 |
| CHEMBL27013 | — | — | 1 | 5.63 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | - |
| CHEMBL29591 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13647 | BMY-7378 | Ki | = | 47.86 | nM | 7.32 |
| CHEMBL341665 | — | Ki | = | 1949.84 | nM | 5.71 |
| CHEMBL27013 | — | Ki | = | 2344.23 | nM | 5.63 |
| CHEMBL2 | PRAZOSIN | Ki | < | 10000.0 | nM | - |
| CHEMBL29591 | — | Ki | < | 10000.0 | nM | - |