Assay Detail
Binding
CHEMBL670975
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Half-maximal inhibition of [3H]spiperone binding to Dopamine receptor D2 in rat striatal homogenate
24
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 7.98 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL303313 | — | — | 1 | 9.40 |
| CHEMBL93240 | METITEPINE | 2.0 | 1 | 9.40 |
| CHEMBL64249 | CLOROTEPINE | 2.0 | 1 | 9.30 |
| CHEMBL2111781 | — | — | 1 | 8.69 |
| CHEMBL118889 | — | — | 1 | 8.51 |
| CHEMBL121274 | — | — | 1 | 8.44 |
| CHEMBL64875 | — | — | 1 | 8.44 |
| CHEMBL120512 | — | — | 1 | 8.42 |
| CHEMBL333955 | — | — | 1 | 8.40 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.32 |
| CHEMBL116542 | — | — | 1 | 8.30 |
| CHEMBL2111783 | — | — | 2 | 8.26 |
| CHEMBL119687 | — | — | 1 | 8.23 |
| CHEMBL333455 | — | — | 1 | 8.02 |
| CHEMBL2111782 | — | — | 2 | 7.72 |
| CHEMBL118919 | — | — | 1 | 7.66 |
| CHEMBL332600 | — | — | 1 | 7.63 |
| CHEMBL118092 | — | — | 1 | 7.53 |
| CHEMBL368324 | — | — | 1 | 7.30 |
| CHEMBL333246 | — | — | 1 | 7.10 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 7.06 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93240 | METITEPINE | Ki | = | 0.3981 | nM | 9.40 |
| CHEMBL303313 | — | Ki | = | 0.3981 | nM | 9.40 |
| CHEMBL64249 | CLOROTEPINE | Ki | = | 0.5012 | nM | 9.30 |
| CHEMBL2111781 | — | Ki | = | 2.042 | nM | 8.69 |
| CHEMBL118889 | — | Ki | = | 3.09 | nM | 8.51 |
| CHEMBL121274 | — | Ki | = | 3.631 | nM | 8.44 |
| CHEMBL64875 | — | Ki | = | 3.631 | nM | 8.44 |
| CHEMBL120512 | — | Ki | = | 3.802 | nM | 8.42 |
| CHEMBL333955 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 4.786 | nM | 8.32 |
| CHEMBL116542 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL2111783 | — | Ki | = | 5.495 | nM | 8.26 |
| CHEMBL119687 | — | Ki | = | 5.888 | nM | 8.23 |
| CHEMBL333455 | — | Ki | = | 9.55 | nM | 8.02 |
| CHEMBL2111782 | — | Ki | = | 19.05 | nM | 7.72 |
| CHEMBL118919 | — | Ki | = | 21.88 | nM | 7.66 |
| CHEMBL332600 | — | Ki | = | 23.44 | nM | 7.63 |
| CHEMBL118092 | — | Ki | = | 29.51 | nM | 7.53 |
| CHEMBL368324 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL333246 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL715 | OLANZAPINE | Ki | = | 87.1 | nM | 7.06 |
| CHEMBL2111783 | — | Ki | = | 245.47 | nM | 6.61 |
| CHEMBL42 | CLOZAPINE | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL2111782 | — | Ki | = | 602.56 | nM | 6.22 |