Assay Detail
Binding
CHEMBL670977
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Displacement of [3H]NPA from rat brain Dopamine receptor D2
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 8.36 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 9.15 |
| CHEMBL35057 | TIOSPIRONE | 2.0 | 1 | 8.67 |
| CHEMBL287605 | — | — | 1 | 8.53 |
| CHEMBL37633 | — | — | 1 | 8.51 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.43 |
| CHEMBL35743 | — | — | 1 | 8.42 |
| CHEMBL35565 | — | — | 1 | 8.38 |
| CHEMBL35040 | — | — | 1 | 8.38 |
| CHEMBL708 | ZIPRASIDONE | 4.0 | 1 | 8.32 |
| CHEMBL284847 | — | — | 1 | 8.29 |
| CHEMBL35085 | — | — | 1 | 8.20 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 0.7079 | nM | 9.15 |
| CHEMBL35057 | TIOSPIRONE | Ki | = | 2.138 | nM | 8.67 |
| CHEMBL287605 | — | Ki | = | 2.951 | nM | 8.53 |
| CHEMBL37633 | — | Ki | = | 3.09 | nM | 8.51 |
| CHEMBL85 | RISPERIDONE | Ki | = | 3.715 | nM | 8.43 |
| CHEMBL35743 | — | Ki | = | 3.802 | nM | 8.42 |
| CHEMBL35565 | — | Ki | = | 4.169 | nM | 8.38 |
| CHEMBL35040 | — | Ki | = | 4.169 | nM | 8.38 |
| CHEMBL708 | ZIPRASIDONE | Ki | = | 4.786 | nM | 8.32 |
| CHEMBL284847 | — | Ki | = | 5.129 | nM | 8.29 |
| CHEMBL35085 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL42 | CLOZAPINE | Ki | = | 83.18 | nM | 7.08 |