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Assay Detail

CHEMBL671323

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Binding
Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

D(1A) dopamine receptor (CHEMBL2967)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Azaindole derivatives with high affinity for the dopamine D4 receptor: synthesis, ligand binding studies and comparison of molecular electrostatic potential maps.
Löber S, Hübner H, Gmeiner P.
Bioorg Med Chem Lett (1999) 9 : 97 -102
PubMed 9990464 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 5.00 6.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL268799 1 6.48
CHEMBL42 CLOZAPINE 4.0 1 6.38
CHEMBL7506 1 5.92
CHEMBL268558 1 5.12
CHEMBL267014 L-745870 1 5.00
CHEMBL269202 1 4.96
CHEMBL7927 FAUC 113 1 4.92
CHEMBL7686 1 4.82
CHEMBL7508 1 4.77
CHEMBL267853 1 4.68
CHEMBL7442 1 4.66
CHEMBL273860 1 4.60
CHEMBL269576 1 4.35
CHEMBL268190 1 4.21
CHEMBL7505 1 4.08
CHEMBL7441 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL268799 Ki = 330.0 nM 6.48
CHEMBL42 CLOZAPINE Ki = 420.0 nM 6.38
CHEMBL7506 Ki = 1200.0 nM 5.92
CHEMBL268558 Ki = 7600.0 nM 5.12
CHEMBL267014 L-745870 Ki = 9900.0 nM 5.00
CHEMBL269202 Ki = 11000.0 nM 4.96
CHEMBL7927 FAUC 113 Ki = 12000.0 nM 4.92
CHEMBL7686 Ki = 15000.0 nM 4.82
CHEMBL7508 Ki = 17000.0 nM 4.77
CHEMBL267853 Ki = 21000.0 nM 4.68
CHEMBL7442 Ki = 22000.0 nM 4.66
CHEMBL273860 Ki = 25000.0 nM 4.60
CHEMBL269576 Ki = 45000.0 nM 4.35
CHEMBL268190 Ki = 62000.0 nM 4.21
CHEMBL7505 Ki = 83000.0 nM 4.08
CHEMBL7441 Ki > 100000.0 nM -