Assay Detail
Binding
CHEMBL671399
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Concentration inhibiting specific binding of [3H]haloperidol to Dopamine receptor D2 from rat striatal brain.
5
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.53 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 7.57 |
| CHEMBL70565 | — | — | 2 | 6.39 |
| CHEMBL69414 | — | — | 1 | 6.10 |
| CHEMBL97424 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL70565 | — | IC50 | = | 409.0 | nM | 6.39 |
| CHEMBL69414 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL70565 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL97424 | — | IC50 | > | 100000.0 | nM | - |