Assay Detail
Binding
CHEMBL671401
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]spiperone binding to rat striatal dopamine receptor D2 was determined in vitro
31
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potential antipsychotic agents. 9. Synthesis and stereoselective dopamine D-2 receptor blockade of a potent class of substituted (R)-N-[(1-benzyl-2-pyrrolidinyl)methyl]benzamides. Relations to other side chain congeners.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.57 | 9.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL172536 | — | — | 1 | 9.44 |
| CHEMBL177762 | — | — | 1 | 9.19 |
| CHEMBL8946 | ETICLOPRIDE | 2.0 | 1 | 9.04 |
| CHEMBL289330 | — | — | 1 | 8.92 |
| CHEMBL435670 | — | — | 1 | 8.89 |
| CHEMBL176458 | — | — | 1 | 8.85 |
| CHEMBL76402 | — | — | 1 | 8.85 |
| CHEMBL176804 | — | — | 1 | 8.62 |
| CHEMBL75842 | — | — | 1 | 8.30 |
| CHEMBL366766 | — | — | 1 | 8.27 |
| CHEMBL123282 | — | — | 1 | 8.20 |
| CHEMBL173536 | — | — | 1 | 8.03 |
| CHEMBL283099 | — | — | 1 | 7.92 |
| CHEMBL2096749 | — | — | 2 | 7.75 |
| CHEMBL173717 | — | — | 1 | 7.68 |
| CHEMBL176373 | — | — | 1 | 7.68 |
| CHEMBL175082 | — | — | 1 | 7.55 |
| CHEMBL172092 | — | — | 1 | 7.54 |
| CHEMBL8809 | RACLOPRIDE | 2.0 | 1 | 7.50 |
| CHEMBL177436 | — | — | 1 | 7.44 |
| CHEMBL174472 | — | — | 1 | 7.39 |
| CHEMBL295621 | — | — | 1 | 7.28 |
| CHEMBL174606 | — | — | 1 | 6.91 |
| CHEMBL1204286 | — | — | 1 | 6.90 |
| CHEMBL171894 | — | — | 1 | 5.73 |
| CHEMBL367751 | — | — | 1 | 5.66 |
| CHEMBL262403 | — | — | 1 | 5.62 |
| CHEMBL172865 | — | — | 1 | 5.46 |
| CHEMBL367065 | — | — | 1 | 4.79 |
| CHEMBL171921 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL172536 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL177762 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL8946 | ETICLOPRIDE | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL289330 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL435670 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL176458 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL76402 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL176804 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL75842 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL366766 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL123282 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL173536 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL283099 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2096749 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL173717 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL176373 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL175082 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL172092 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL8809 | RACLOPRIDE | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL177436 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL174472 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL295621 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL174606 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL1204286 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL171894 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL367751 | — | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL262403 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL2096749 | — | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL172865 | — | IC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL367065 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL171921 | — | IC50 | > | 10000.0 | nM | - |