Assay Detail
Binding
CHEMBL671403
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]- -spiperone from Dopamine receptor D2 in rat striatum
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective dopamine D1 full agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.62 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL299161 | — | — | 1 | 7.28 |
| CHEMBL299430 | — | — | 1 | 7.17 |
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 7.00 |
| CHEMBL25856 | DIHYDREXIDINE | 2.0 | 1 | 6.92 |
| CHEMBL51017 | — | — | 1 | 6.87 |
| CHEMBL49634 | — | — | 1 | 6.54 |
| CHEMBL407489 | — | — | 1 | 6.54 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 5.82 |
| CHEMBL24077 | (R)-SKF-38393 | — | 1 | 5.43 |
| CHEMBL43345 | — | — | 1 | - |
| CHEMBL62 | SCH-23390 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL299161 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL299430 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL240773 | QUINPIROLE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL25856 | DIHYDREXIDINE | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL51017 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL49634 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL407489 | — | IC50 | = | 285.0 | nM | 6.54 |
| CHEMBL59 | DOPAMINE | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL24077 | (R)-SKF-38393 | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL43345 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL62 | SCH-23390 | IC50 | > | 10000.0 | nM | - |