Assay Detail
Binding
CHEMBL671404
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Displacement of [3H]raclopride at Dopamine receptor D2 in brain striata (n=1)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(heteroarylalkynyl)-4-benzylpiperidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.06 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19506 | — | — | 1 | 5.77 |
| CHEMBL117260 | — | — | 1 | 5.58 |
| CHEMBL325825 | — | — | 1 | 5.43 |
| CHEMBL19636 | — | — | 1 | 5.41 |
| CHEMBL326568 | — | — | 1 | 5.00 |
| CHEMBL419399 | — | — | 1 | 4.85 |
| CHEMBL19576 | — | — | 1 | 4.39 |
| CHEMBL326742 | — | — | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19506 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL117260 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL325825 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL19636 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL326568 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL419399 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL19576 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL326742 | — | IC50 | = | 86000.0 | nM | 4.07 |