Assay Detail
Binding
CHEMBL671405
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Evaluated for the affinity against Dopamine receptor D2 in rat striatal membranes
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Preparation of 7-oxaaporphine derivatives and evaluation of their dopaminergic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.50 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 9.00 |
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | IC50 | = | 10.0 | nM | 8.00 |