Assay Detail
Binding
CHEMBL671408
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In vitro agonist binding affinity was determined by displacing the [3H]N-propylnorapomorphine ([3H]NPA) in rat striatal Dopamine receptor D2
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological evaluation of the enantiomers of the dopamine autoreceptor agonist PD 135385
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.36 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 8.77 |
| CHEMBL348547 | — | — | 1 | 7.19 |
| CHEMBL418937 | — | — | 1 | 7.09 |
| CHEMBL160672 | — | — | 1 | 7.06 |
| CHEMBL350920 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL348547 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL418937 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL160672 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL350920 | — | IC50 | = | 202.0 | nM | 6.70 |