Assay Detail
Binding
CHEMBL671409
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from rat striatal Dopamine receptor D2
13
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacological evaluation of the enantiomers of the dopamine autoreceptor agonist PD 135385
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.32 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 7.62 |
| CHEMBL346075 | — | — | 1 | 6.89 |
| CHEMBL157087 | — | — | 1 | 6.45 |
| CHEMBL160672 | — | — | 2 | 6.38 |
| CHEMBL346940 | — | — | 1 | 6.36 |
| CHEMBL348547 | — | — | 1 | 6.26 |
| CHEMBL157422 | — | — | 1 | 6.22 |
| CHEMBL418937 | — | — | 1 | 6.15 |
| CHEMBL422187 | — | — | 1 | 5.93 |
| CHEMBL349994 | — | — | 1 | 5.61 |
| CHEMBL350920 | — | — | 1 | 5.54 |
| CHEMBL349568 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL346075 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL157087 | — | IC50 | = | 352.0 | nM | 6.45 |
| CHEMBL160672 | — | IC50 | = | 412.0 | nM | 6.38 |
| CHEMBL160672 | — | IC50 | = | 412.0 | nM | 6.38 |
| CHEMBL346940 | — | IC50 | = | 436.0 | nM | 6.36 |
| CHEMBL348547 | — | IC50 | = | 545.0 | nM | 6.26 |
| CHEMBL157422 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL418937 | — | IC50 | = | 704.0 | nM | 6.15 |
| CHEMBL422187 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL349994 | — | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL350920 | — | IC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL349568 | — | IC50 | ~ | 10000.0 | nM | - |