Assay Detail
Binding
CHEMBL671414
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity against Dopamine receptor D2 by displacement of [3H]haloperidol from rat striatal membranes.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1,3-Dialkyl-4-(iminoarylmethyl)-1H-pyrazol-5-ols. A series of novel potential antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.99 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL479 | THIORIDAZINE | 4.0 | 1 | 8.55 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.42 |
| CHEMBL3144745 | — | — | 1 | - |
| CHEMBL3144764 | — | — | 1 | - |
| CHEMBL3144759 | — | — | 1 | - |
| CHEMBL3144805 | — | — | 1 | - |
| CHEMBL3144629 | — | — | 1 | - |
| CHEMBL3144848 | — | — | 1 | - |
| CHEMBL3144748 | — | — | 1 | - |
| CHEMBL3144637 | — | — | 1 | - |
| CHEMBL3144634 | — | — | 1 | - |
| CHEMBL3144620 | — | — | 1 | - |
| CHEMBL3144642 | — | — | 1 | - |
| CHEMBL3144632 | — | — | 1 | - |
| CHEMBL3144756 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL479 | THIORIDAZINE | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3144745 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3144764 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3144759 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3144805 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3144629 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3144848 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3144748 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3144637 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3144634 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3144620 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3144642 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3144632 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3144756 | — | IC50 | > | 10000.0 | nM | - |