Assay Detail
Functional
CHEMBL671445
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity of compound for D2 receptor in rat striatal membrane determined for agonist state (high affinity state, D2 High) [3H]quinpirole as radioligand (in the absence of GTP and sodium)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New generation dopaminergic agents. Part 8: heterocyclic bioisosteres that exploit the 7-OH-2-(aminomethyl)chroman D(2) template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 9.25 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL420986 | — | — | 1 | 10.15 |
| CHEMBL93779 | — | — | 1 | 9.85 |
| CHEMBL303556 | — | — | 1 | 9.85 |
| CHEMBL64553 | — | — | 1 | 9.70 |
| CHEMBL60185 | — | — | 1 | 8.72 |
| CHEMBL93753 | — | — | 1 | 8.26 |
| CHEMBL313851 | — | — | 1 | 8.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL420986 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL93779 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL303556 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL64553 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL60185 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL93753 | — | Ki | = | 5.45 | nM | 8.26 |
| CHEMBL313851 | — | Ki | = | 5.75 | nM | 8.24 |