Assay Detail
Binding
CHEMBL671494
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against D2 receptor in rat corpus striatum using [3H]sulpiride as the radioligand
46
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and in vitro evaluation of 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles: high-affinity ligands for the N,N'-di-o-tolylguanidine-labeled sigma binding site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 46 | 5.70 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL442395 | — | — | 1 | 8.22 |
| CHEMBL119047 | — | — | 1 | 7.00 |
| CHEMBL36645 | — | — | 1 | 6.57 |
| CHEMBL117898 | — | — | 4 | 6.48 |
| CHEMBL324092 | — | — | 1 | 6.28 |
| CHEMBL119867 | — | — | 1 | 6.21 |
| CHEMBL118289 | — | — | 1 | 6.19 |
| CHEMBL332035 | — | — | 1 | 6.17 |
| CHEMBL325845 | — | — | 1 | 6.15 |
| CHEMBL38130 | — | — | 1 | 6.13 |
| CHEMBL35711 | — | — | 1 | 6.11 |
| CHEMBL119804 | — | — | 1 | 6.08 |
| CHEMBL38152 | — | — | 1 | 5.94 |
| CHEMBL119048 | — | — | 1 | 5.89 |
| CHEMBL433022 | — | — | 1 | 5.80 |
| CHEMBL118665 | — | — | 1 | 5.79 |
| CHEMBL116711 | — | — | 1 | 5.75 |
| CHEMBL331500 | — | — | 1 | 5.74 |
| CHEMBL119075 | — | — | 1 | 5.74 |
| CHEMBL116207 | — | — | 1 | 5.70 |
| CHEMBL119811 | — | — | 1 | 5.68 |
| CHEMBL115582 | — | — | 1 | 5.65 |
| CHEMBL117567 | — | — | 1 | 5.62 |
| CHEMBL119485 | — | — | 1 | 5.61 |
| CHEMBL116710 | — | — | 1 | 5.60 |
| CHEMBL119889 | — | — | 1 | 5.58 |
| CHEMBL332593 | — | — | 1 | 5.58 |
| CHEMBL333840 | — | — | 1 | 5.58 |
| CHEMBL285203 | — | — | 1 | 5.52 |
| CHEMBL325619 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL442395 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL119047 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL36645 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL117898 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL324092 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL119867 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL118289 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL332035 | — | Ki | = | 677.0 | nM | 6.17 |
| CHEMBL325845 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL38130 | — | Ki | = | 733.0 | nM | 6.13 |
| CHEMBL35711 | — | Ki | = | 769.0 | nM | 6.11 |
| CHEMBL119804 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL38152 | — | Ki | = | 1160.0 | nM | 5.94 |
| CHEMBL117898 | — | Ki | = | 1270.0 | nM | 5.90 |
| CHEMBL117898 | — | Ki | = | 1270.0 | nM | 5.90 |
| CHEMBL119048 | — | Ki | = | 1280.0 | nM | 5.89 |
| CHEMBL433022 | — | Ki | = | 1570.0 | nM | 5.80 |
| CHEMBL118665 | — | Ki | = | 1620.0 | nM | 5.79 |
| CHEMBL116711 | — | Ki | = | 1780.0 | nM | 5.75 |
| CHEMBL119075 | — | Ki | = | 1820.0 | nM | 5.74 |
| CHEMBL331500 | — | Ki | = | 1830.0 | nM | 5.74 |
| CHEMBL116207 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL119811 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL115582 | — | Ki | = | 2230.0 | nM | 5.65 |
| CHEMBL117567 | — | Ki | = | 2420.0 | nM | 5.62 |
| CHEMBL119485 | — | Ki | = | 2460.0 | nM | 5.61 |
| CHEMBL116710 | — | Ki | = | 2530.0 | nM | 5.60 |
| CHEMBL332593 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL333840 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL119889 | — | Ki | = | 2640.0 | nM | 5.58 |
| CHEMBL285203 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL117898 | — | Ki | = | 3150.0 | nM | 5.50 |
| CHEMBL325619 | — | Ki | = | 3430.0 | nM | 5.46 |
| CHEMBL118288 | — | Ki | = | 3650.0 | nM | 5.44 |
| CHEMBL117748 | — | Ki | = | 3790.0 | nM | 5.42 |
| CHEMBL331611 | — | Ki | = | 4520.0 | nM | 5.34 |
| CHEMBL323910 | — | Ki | = | 5310.0 | nM | 5.28 |
| CHEMBL118445 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL119495 | — | Ki | = | 11200.0 | nM | 4.95 |
| CHEMBL325168 | — | Ki | = | 12200.0 | nM | 4.91 |
| CHEMBL119725 | — | Ki | = | 12300.0 | nM | 4.91 |
| CHEMBL118276 | — | Ki | = | 16600.0 | nM | 4.78 |
| CHEMBL331006 | — | Ki | = | 36600.0 | nM | 4.44 |
| CHEMBL119409 | — | Ki | = | 37300.0 | nM | 4.43 |
| CHEMBL119698 | — | Ki | = | 52100.0 | nM | 4.28 |
| CHEMBL117695 | — | Ki | > | 10000.0 | nM | - |