Assay Detail
Binding
CHEMBL671496
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Binding affinity rat Dopamine receptor D2 expressed in CHO-K1 cells by [3H]U-86170 displacement.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 2. Effects of 8-amino nitrogen substitution on serotonin receptor binding and pharmacology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 7.62 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL306197 | — | — | 1 | 8.32 |
| CHEMBL71145 | — | — | 1 | 8.26 |
| CHEMBL1788200 | — | — | 1 | 8.19 |
| CHEMBL302172 | — | — | 1 | 8.13 |
| CHEMBL69943 | — | — | 1 | 7.82 |
| CHEMBL65196 | — | — | 1 | 7.82 |
| CHEMBL303339 | — | — | 1 | 7.82 |
| CHEMBL420748 | — | — | 1 | 7.82 |
| CHEMBL302171 | — | — | 1 | 7.77 |
| CHEMBL70606 | — | — | 1 | 7.66 |
| CHEMBL413105 | — | — | 1 | 7.62 |
| CHEMBL70980 | — | — | 1 | 7.50 |
| CHEMBL69729 | — | — | 1 | 7.48 |
| CHEMBL71409 | — | — | 1 | 7.48 |
| CHEMBL309121 | — | — | 1 | 7.38 |
| CHEMBL305976 | — | — | 1 | 7.32 |
| CHEMBL69560 | — | — | 1 | 7.03 |
| CHEMBL73112 | — | — | 1 | 7.00 |
| CHEMBL292274 | — | — | 1 | 6.42 |
| CHEMBL70489 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL306197 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL71145 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL1788200 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL302172 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL69943 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL65196 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL303339 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL420748 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL302171 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL70606 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL413105 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL70980 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL69729 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL71409 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL309121 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL305976 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL69560 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL73112 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL292274 | — | Ki | = | 377.0 | nM | 6.42 |
| CHEMBL70489 | — | Ki | > | 1000.0 | nM | - |