Assay Detail
Binding
CHEMBL671507
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Binding affinity for dopamine receptor D2
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacological evaluation of 1-(aminomethyl)-3,4-dihydro-5-hydroxy-1H-2-benzopyrans as dopamine D1 selective ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.66 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL543390 | — | — | 1 | 6.25 |
| CHEMBL86931 | — | — | 1 | 6.11 |
| CHEMBL62 | SCH-23390 | — | 1 | 6.05 |
| CHEMBL100572 | — | — | 1 | 5.95 |
| CHEMBL538520 | — | — | 1 | 5.71 |
| CHEMBL543389 | — | — | 1 | 5.58 |
| CHEMBL544099 | — | — | 1 | 5.34 |
| CHEMBL24077 | (R)-SKF-38393 | — | 1 | 5.16 |
| CHEMBL545264 | — | — | 1 | 4.75 |
| CHEMBL542436 | — | — | 1 | - |
| CHEMBL555619 | — | — | 1 | - |
| CHEMBL541838 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL543390 | — | Ki | = | 569.0 | nM | 6.25 |
| CHEMBL86931 | — | Ki | = | 776.0 | nM | 6.11 |
| CHEMBL62 | SCH-23390 | Ki | = | 886.0 | nM | 6.05 |
| CHEMBL100572 | — | Ki | = | 1120.0 | nM | 5.95 |
| CHEMBL538520 | — | Ki | = | 1960.0 | nM | 5.71 |
| CHEMBL543389 | — | Ki | = | 2630.0 | nM | 5.58 |
| CHEMBL544099 | — | Ki | = | 4610.0 | nM | 5.34 |
| CHEMBL24077 | (R)-SKF-38393 | Ki | = | 6865.0 | nM | 5.16 |
| CHEMBL545264 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL542436 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL555619 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL541838 | — | Ki | > | 30000.0 | nM | - |