Assay Detail
Binding
CHEMBL671570
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Binding affinity of compound against Dopamine receptor D2 binding site using radioligand [3H]spiperone
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
5-HT1A-receptor antagonism: N-alkyl derivatives of (R)-(-)-8,11-dimethoxynoraporphine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.15 | 10.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 10.35 |
| CHEMBL300329 | — | — | 1 | 6.68 |
| CHEMBL61377 | — | — | 1 | 6.11 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267930 | SPIPERONE | Ki | = | 0.045 | nM | 10.35 |
| CHEMBL300329 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL61377 | — | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 3500.0 | nM | 5.46 |