Assay Detail

CHEMBL671575

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Binding

Binding affinity against Dopamine receptor D2 of rat was determined using 2 nM of [3H]sulpiride in binding assay

ChEMBL ↗

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Target

D(2) dopamine receptor (CHEMBL339) ↗

Open DB target context

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D(2) dopamine receptor (CHEMBL339) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target D(2) dopamine receptor

CHEMBL339

Anchored from Assay target.

Protein identity D(2) dopamine receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

D(2) dopamine receptor (CHEMBL339) ↗

Type	SINGLE PROTEIN
Organism	Rattus norvegicus

Publication

Serotonergic properties of spiroxatrine enantiomers.

Nikam SS, Martin AR, Nelson DL.
J Med Chem (1988) 31 : 1965 -1968
PubMed 2902227 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	2	9.25	9.66

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL300555	SPIROXATRINE	2.0	2	9.66

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL300555	SPIROXATRINE	Ki	=	0.22	nM	9.66
CHEMBL300555	SPIROXATRINE	Ki	=	1.45	nM	8.84