Assay Detail

CHEMBL671577

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Binding

Binding affinity to dopamine receptor D2

ChEMBL ↗

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Target

D(2) dopamine receptor (CHEMBL339) ↗

Open DB target context

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D(2) dopamine receptor (CHEMBL339) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target D(2) dopamine receptor

CHEMBL339

Anchored from Assay target.

Protein identity D(2) dopamine receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

D(2) dopamine receptor (CHEMBL339) ↗

Type	SINGLE PROTEIN
Organism	Rattus norvegicus

Publication

SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype.

Flynn DL, Zabrowski DL, Becker DP, Nosal R, Villamil CI, Gullikson GW, Moummi C, Yang DC.
J Med Chem (1992) 35 : 1486 -1489
PubMed 1573641 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	6.95	6.95

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL86	METOCLOPRAMIDE	4.0	1	6.95

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL86	METOCLOPRAMIDE	Ki	=	113.0	nM	6.95