Assay Detail
Binding
CHEMBL671579
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to rat Dopamine receptor D2 expressed in CHO cells was determined using [125 I ] iodosulpride as radioligand
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Dopamine D3 and D4 receptor antagonists: synthesis and structure--activity relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl) amino]-2-methoxybenzamide (YM-43611) and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 7.27 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20734 | NEMONAPRIDE | 2.0 | 1 | 9.80 |
| CHEMBL319597 | — | — | 1 | 9.09 |
| CHEMBL329106 | — | — | 1 | 9.01 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.96 |
| CHEMBL327984 | — | — | 1 | 8.92 |
| CHEMBL330318 | — | — | 1 | 7.92 |
| CHEMBL92199 | — | — | 1 | 7.70 |
| CHEMBL92192 | — | — | 1 | 7.57 |
| CHEMBL96703 | — | — | 1 | 7.50 |
| CHEMBL93198 | — | — | 1 | 7.50 |
| CHEMBL93021 | — | — | 1 | 7.30 |
| CHEMBL91859 | — | — | 1 | 7.09 |
| CHEMBL96369 | — | — | 1 | 7.08 |
| CHEMBL92924 | — | — | 1 | 6.96 |
| CHEMBL94050 | — | — | 1 | 6.85 |
| CHEMBL315446 | — | — | 1 | 6.77 |
| CHEMBL319079 | — | — | 1 | 6.72 |
| CHEMBL328866 | — | — | 1 | 6.66 |
| CHEMBL316317 | — | — | 1 | 6.62 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.58 |
| CHEMBL91693 | — | — | 1 | 6.20 |
| CHEMBL94200 | — | — | 1 | 6.16 |
| CHEMBL92030 | — | — | 1 | 6.13 |
| CHEMBL95096 | — | — | 1 | 5.92 |
| CHEMBL96792 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20734 | NEMONAPRIDE | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL319597 | — | Ki | = | 0.81 | nM | 9.09 |
| CHEMBL329106 | — | Ki | = | 0.98 | nM | 9.01 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL327984 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL330318 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL92199 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL92192 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL96703 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL93198 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL93021 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL91859 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL96369 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL92924 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL94050 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL315446 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL319079 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL328866 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL316317 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL42 | CLOZAPINE | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL91693 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL94200 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL92030 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL95096 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL96792 | — | Ki | = | 14000.0 | nM | 4.85 |