Assay Detail
Binding
CHEMBL671583
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In vitro binding affinity towards Dopamine receptor D2 in rat striatum was determined using [3H]spiperone as radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Characterization of potent and selective antagonists at postsynaptic 5-HT1A receptors in a series of N4-substituted arylpiperazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.31 | 7.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL131900 | — | — | 1 | 7.71 |
| CHEMBL8618 | NAN-190 | — | 1 | 7.50 |
| CHEMBL127216 | — | — | 1 | 6.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL131900 | — | Ki | = | 19.5 | nM | 7.71 |
| CHEMBL8618 | NAN-190 | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL127216 | — | Ki | = | 194.98 | nM | 6.71 |