Assay Detail
Binding
CHEMBL671586
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Inhibition of [3H]-spiperone 23390 binding to dopamine receptor D2 rat striatal membrane
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and atypical antipsychotic profile of some 2-(2-piperidinoethyl)benzocycloalkanones as analogues of butyrophenone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.48 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.30 |
| CHEMBL87026 | — | — | 1 | 7.33 |
| CHEMBL87458 | — | — | 1 | 7.32 |
| CHEMBL87943 | — | — | 1 | 7.32 |
| CHEMBL87717 | — | — | 1 | 7.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL87026 | — | Ki | = | 46.77 | nM | 7.33 |
| CHEMBL87458 | — | Ki | = | 47.86 | nM | 7.32 |
| CHEMBL87943 | — | Ki | = | 47.86 | nM | 7.32 |
| CHEMBL87717 | — | Ki | = | 70.79 | nM | 7.15 |