Assay Detail
Binding
CHEMBL671589
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pKi value for Dopamine receptor D2 binding site
7
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New antipsychotic agents with serotonin and dopamine antagonist properties based on a pyrrolo[2,1-b][1,3]benzothiazepine structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.86 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122536 | METHIOTHEPINE | — | 1 | 9.70 |
| CHEMBL120512 | — | — | 3 | 8.70 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 7.20 |
| CHEMBL333246 | — | — | 1 | 7.15 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122536 | METHIOTHEPINE | Ki | = | 0.1995 | nM | 9.70 |
| CHEMBL120512 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL120512 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL120512 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL715 | OLANZAPINE | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL333246 | — | Ki | = | 70.79 | nM | 7.15 |
| CHEMBL42 | CLOZAPINE | Ki | = | 251.19 | nM | 6.60 |