Assay Detail
Binding
CHEMBL671591
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against dopamine receptor D2 on rat striatum using [3H]spiperone as radioligand.
30
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacological characterization of novel 6-fluorochroman derivatives as potential 5-HT1A receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 7.97 | 9.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96279 | — | — | 1 | 9.83 |
| CHEMBL25213 | — | — | 1 | 9.59 |
| CHEMBL419147 | — | — | 1 | 9.54 |
| CHEMBL96222 | — | — | 1 | 9.51 |
| CHEMBL96714 | — | — | 3 | 9.32 |
| CHEMBL96546 | — | — | 1 | 8.64 |
| CHEMBL96517 | — | — | 1 | 8.52 |
| CHEMBL95044 | — | — | 1 | 8.52 |
| CHEMBL92651 | — | — | 1 | 8.30 |
| CHEMBL96578 | — | — | 1 | 8.09 |
| CHEMBL318418 | — | — | 1 | 8.04 |
| CHEMBL96858 | — | — | 1 | 7.93 |
| CHEMBL319575 | — | — | 1 | 7.63 |
| CHEMBL96901 | — | — | 1 | 7.62 |
| CHEMBL93503 | — | — | 1 | 7.60 |
| CHEMBL96265 | — | — | 1 | 7.49 |
| CHEMBL94957 | — | — | 1 | 7.46 |
| CHEMBL96435 | — | — | 1 | 7.42 |
| CHEMBL96266 | — | — | 1 | 7.41 |
| CHEMBL94317 | — | — | 1 | 7.38 |
| CHEMBL330714 | — | — | 1 | 7.36 |
| CHEMBL318417 | — | — | 1 | 7.30 |
| CHEMBL329675 | — | — | 1 | 7.26 |
| CHEMBL93030 | — | — | 1 | 7.21 |
| CHEMBL96903 | — | — | 1 | 7.15 |
| CHEMBL94428 | — | — | 1 | 6.96 |
| CHEMBL317532 | — | — | 1 | 6.82 |
| CHEMBL316593 | — | — | 1 | 5.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96279 | — | Ki | = | 0.149 | nM | 9.83 |
| CHEMBL25213 | — | Ki | = | 0.259 | nM | 9.59 |
| CHEMBL419147 | — | Ki | = | 0.288 | nM | 9.54 |
| CHEMBL96222 | — | Ki | = | 0.312 | nM | 9.51 |
| CHEMBL96714 | — | Ki | = | 0.482 | nM | 9.32 |
| CHEMBL96714 | — | Ki | = | 0.724 | nM | 9.14 |
| CHEMBL96546 | — | Ki | = | 2.31 | nM | 8.64 |
| CHEMBL96517 | — | Ki | = | 2.99 | nM | 8.52 |
| CHEMBL95044 | — | Ki | = | 3.02 | nM | 8.52 |
| CHEMBL96714 | — | Ki | = | 4.11 | nM | 8.39 |
| CHEMBL92651 | — | Ki | = | 4.98 | nM | 8.30 |
| CHEMBL96578 | — | Ki | = | 8.13 | nM | 8.09 |
| CHEMBL318418 | — | Ki | = | 9.07 | nM | 8.04 |
| CHEMBL96858 | — | Ki | = | 11.7 | nM | 7.93 |
| CHEMBL319575 | — | Ki | = | 23.3 | nM | 7.63 |
| CHEMBL96901 | — | Ki | = | 23.7 | nM | 7.62 |
| CHEMBL93503 | — | Ki | = | 25.1 | nM | 7.60 |
| CHEMBL96265 | — | Ki | = | 32.3 | nM | 7.49 |
| CHEMBL94957 | — | Ki | = | 34.6 | nM | 7.46 |
| CHEMBL96435 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL96266 | — | Ki | = | 38.8 | nM | 7.41 |
| CHEMBL94317 | — | Ki | = | 42.1 | nM | 7.38 |
| CHEMBL330714 | — | Ki | = | 43.9 | nM | 7.36 |
| CHEMBL318417 | — | Ki | = | 49.6 | nM | 7.30 |
| CHEMBL329675 | — | Ki | = | 55.1 | nM | 7.26 |
| CHEMBL93030 | — | Ki | = | 62.3 | nM | 7.21 |
| CHEMBL96903 | — | Ki | = | 70.4 | nM | 7.15 |
| CHEMBL94428 | — | Ki | = | 111.0 | nM | 6.96 |
| CHEMBL317532 | — | Ki | = | 153.0 | nM | 6.82 |
| CHEMBL316593 | — | Ki | = | 1540.0 | nM | 5.81 |