Assay Detail
Binding
CHEMBL671731
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In vitro binding affinity at human cloned dopamine receptor D2 (long) stably expressed in CHO cells by [3H]-Spiperone displacement.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Di- and trisubstituted pyrazolo[1,5-a]pyridine derivatives: synthesis, dopamine receptor binding and ligand efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 5.24 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.39 |
| CHEMBL160536 | — | — | 1 | 6.52 |
| CHEMBL160266 | — | — | 1 | 6.19 |
| CHEMBL160454 | — | — | 1 | 5.51 |
| CHEMBL7927 | FAUC 113 | — | 1 | 5.50 |
| CHEMBL160952 | — | — | 1 | 5.43 |
| CHEMBL423247 | — | — | 1 | 5.31 |
| CHEMBL155913 | — | — | 1 | 5.27 |
| CHEMBL346805 | — | — | 1 | 5.02 |
| CHEMBL156369 | — | — | 1 | 4.89 |
| CHEMBL160749 | — | — | 1 | 4.85 |
| CHEMBL156198 | — | — | 1 | 4.82 |
| CHEMBL156851 | — | — | 1 | 4.68 |
| CHEMBL351550 | — | — | 1 | 4.55 |
| CHEMBL345357 | — | — | 1 | 4.55 |
| CHEMBL267014 | L-745870 | — | 1 | 4.27 |
| CHEMBL160396 | — | — | 1 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL160536 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL160266 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL160454 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL7927 | FAUC 113 | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL160952 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL423247 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL155913 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL346805 | — | Ki | = | 9500.0 | nM | 5.02 |
| CHEMBL156369 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL160749 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL156198 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL156851 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL351550 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL345357 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL267014 | L-745870 | Ki | = | 54000.0 | nM | 4.27 |
| CHEMBL160396 | — | Ki | = | 56000.0 | nM | 4.25 |