Compound Detail
CHEMBL160454
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL160454 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VLCYCTQMMKCUDI-UHFFFAOYSA-N |
4
Targets
5
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
399.0
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 5 meas. best 8.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(4) dopamine receptor CHEMBL219 | Ki | 8.55 | 8.55 | 2.8 | 1 |
| D(3) dopamine receptor CHEMBL234 | Ki | 5.7 | 5.7 | 2000.0 | 1 |
| D(2) dopamine receptor CHEMBL217 | Ki | 5.55 | 5.53 | 2800.0 | 2 |
| D(1A) dopamine receptor CHEMBL2967 | Ki | 5.15 | 5.15 | 7100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(4) dopamine receptor | Ki | = | 2.8 | nM | 8.55 | In vitro binding affinity at human cloned dopamine receptor D4 stably expressed ... | 11844688 |
| D(3) dopamine receptor | Ki | = | 2000.0 | nM | 5.7 | In vitro binding affinity at human cloned dopamine receptor D3 stably expressed ... | 11844688 |
| D(2) dopamine receptor | Ki | = | 2800.0 | nM | 5.55 | In vitro binding affinity at human cloned dopamine receptor D2 (short) stably ex... | 11844688 |
| D(2) dopamine receptor | Ki | = | 3100.0 | nM | 5.51 | In vitro binding affinity at human cloned dopamine receptor D2 (long) stably exp... | 11844688 |
| D(1A) dopamine receptor | Ki | = | 7100.0 | nM | 5.15 | In vitro binding affinity at human cloned dopamine receptor D1 stably expressed ... | 11844688 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11844688 | 10.1016/s0960-894x(01)00814-9 | D(2) dopamine receptor | 2 |
| 11844688 | 10.1016/s0960-894x(01)00814-9 | D(1A) dopamine receptor | 1 |
| 11844688 | 10.1016/s0960-894x(01)00814-9 | D(3) dopamine receptor | 1 |
| 11844688 | 10.1016/s0960-894x(01)00814-9 | D(4) dopamine receptor | 1 |
Data from ChEMBL 36 via Core Engine