Assay Detail
Binding
CHEMBL671322
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In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Di- and trisubstituted pyrazolo[1,5-a]pyridine derivatives: synthesis, dopamine receptor binding and ligand efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 5.53 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.38 |
| CHEMBL160952 | — | — | 1 | 6.09 |
| CHEMBL155913 | — | — | 1 | 6.03 |
| CHEMBL160749 | — | — | 1 | 6.00 |
| CHEMBL346805 | — | — | 1 | 5.92 |
| CHEMBL345357 | — | — | 1 | 5.85 |
| CHEMBL160266 | — | — | 1 | 5.82 |
| CHEMBL160536 | — | — | 1 | 5.82 |
| CHEMBL423247 | — | — | 1 | 5.66 |
| CHEMBL160626 | — | — | 1 | 5.60 |
| CHEMBL351550 | — | — | 1 | 5.48 |
| CHEMBL160396 | — | — | 1 | 5.32 |
| CHEMBL156198 | — | — | 1 | 5.16 |
| CHEMBL156369 | — | — | 1 | 5.16 |
| CHEMBL160454 | — | — | 1 | 5.15 |
| CHEMBL267014 | L-745870 | — | 1 | 5.00 |
| CHEMBL160932 | — | — | 1 | 4.96 |
| CHEMBL7927 | FAUC 113 | — | 1 | 4.92 |
| CHEMBL156851 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL160952 | — | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL155913 | — | Ki | = | 930.0 | nM | 6.03 |
| CHEMBL160749 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL346805 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL345357 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL160266 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL160536 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL423247 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL160626 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL351550 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL160396 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL156198 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL156369 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL160454 | — | Ki | = | 7100.0 | nM | 5.15 |
| CHEMBL267014 | L-745870 | Ki | = | 9900.0 | nM | 5.00 |
| CHEMBL160932 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL7927 | FAUC 113 | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL156851 | — | Ki | = | 15000.0 | nM | 4.82 |