Assay Detail
Binding
CHEMBL671740
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested in vitro for its ability to inhibit [3H]spiperone binding to Dopamine receptor D2 in rat striatal membrane
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New cyclic butyrophenone derivatives in the indole series as potential atypical antipsychotics. A simple and practical synthesis of 6-aminomethyl-tetrahydroindol-4-ones and their affinites for D2 and 5-HT2A receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.94 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.30 |
| CHEMBL460 | MOLINDONE | 4.0 | 1 | 7.48 |
| CHEMBL163012 | — | — | 1 | 7.04 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.00 |
| CHEMBL163605 | — | — | 1 | 6.55 |
| CHEMBL162901 | — | — | 1 | 6.20 |
| CHEMBL349832 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL460 | MOLINDONE | Ki | = | 33.11 | nM | 7.48 |
| CHEMBL163012 | — | Ki | = | 91.2 | nM | 7.04 |
| CHEMBL42 | CLOZAPINE | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL163605 | — | Ki | = | 281.84 | nM | 6.55 |
| CHEMBL162901 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL349832 | — | Ki | = | 954.99 | nM | 6.02 |