Assay Detail
Binding
CHEMBL671741
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro ability to displace [3H]spiperone binding from dopamine receptor D2 in rat striatal membrane.
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Conformationally constrained butyrophenones with mixed dopaminergic (D(2)) and serotoninergic (5-HT(2A), 5-HT(2C)) affinities: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo- and -thienocycloalkanones as putative atypical antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 7.15 | 9.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | — | 1 | 9.27 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.48 |
| CHEMBL310153 | — | — | 1 | 8.19 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.09 |
| CHEMBL554199 | — | — | 1 | 7.70 |
| CHEMBL308480 | — | — | 1 | 7.68 |
| CHEMBL92145 | — | — | 1 | 7.64 |
| CHEMBL310734 | — | — | 1 | 7.60 |
| CHEMBL541842 | — | — | 1 | 7.36 |
| CHEMBL543613 | — | — | 1 | 7.34 |
| CHEMBL87026 | — | — | 1 | 7.33 |
| CHEMBL87943 | — | — | 1 | 7.32 |
| CHEMBL539544 | — | — | 1 | 7.26 |
| CHEMBL95098 | — | — | 1 | 7.17 |
| CHEMBL87717 | — | — | 1 | 7.15 |
| CHEMBL96781 | — | — | 1 | 7.04 |
| CHEMBL540822 | — | — | 1 | 6.79 |
| CHEMBL558817 | — | — | 1 | 6.76 |
| CHEMBL544091 | — | — | 1 | 6.68 |
| CHEMBL545488 | — | — | 1 | 6.65 |
| CHEMBL95112 | — | — | 1 | 6.58 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.58 |
| CHEMBL542428 | — | — | 1 | 6.57 |
| CHEMBL544319 | — | — | 1 | 6.50 |
| CHEMBL544089 | — | — | 1 | 6.49 |
| CHEMBL544318 | — | — | 1 | 6.49 |
| CHEMBL92673 | — | — | 1 | 6.39 |
| CHEMBL542181 | — | — | 1 | 6.19 |
| CHEMBL545727 | — | — | 1 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | Ki | = | 0.537 | nM | 9.27 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 3.311 | nM | 8.48 |
| CHEMBL310153 | — | Ki | = | 6.457 | nM | 8.19 |
| CHEMBL85 | RISPERIDONE | Ki | = | 8.128 | nM | 8.09 |
| CHEMBL554199 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL308480 | — | Ki | = | 20.89 | nM | 7.68 |
| CHEMBL92145 | — | Ki | = | 22.91 | nM | 7.64 |
| CHEMBL310734 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL541842 | — | Ki | = | 43.65 | nM | 7.36 |
| CHEMBL543613 | — | Ki | = | 45.71 | nM | 7.34 |
| CHEMBL87026 | — | Ki | = | 46.77 | nM | 7.33 |
| CHEMBL87943 | — | Ki | = | 47.86 | nM | 7.32 |
| CHEMBL539544 | — | Ki | = | 54.95 | nM | 7.26 |
| CHEMBL95098 | — | Ki | = | 67.61 | nM | 7.17 |
| CHEMBL87717 | — | Ki | = | 70.79 | nM | 7.15 |
| CHEMBL96781 | — | Ki | = | 91.2 | nM | 7.04 |
| CHEMBL540822 | — | Ki | = | 162.18 | nM | 6.79 |
| CHEMBL558817 | — | Ki | = | 173.78 | nM | 6.76 |
| CHEMBL544091 | — | Ki | = | 208.93 | nM | 6.68 |
| CHEMBL545488 | — | Ki | = | 223.87 | nM | 6.65 |
| CHEMBL95112 | — | Ki | = | 263.03 | nM | 6.58 |
| CHEMBL42 | CLOZAPINE | Ki | = | 263.03 | nM | 6.58 |
| CHEMBL542428 | — | Ki | = | 269.15 | nM | 6.57 |
| CHEMBL544319 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL544089 | — | Ki | = | 323.59 | nM | 6.49 |
| CHEMBL544318 | — | Ki | = | 323.59 | nM | 6.49 |
| CHEMBL92673 | — | Ki | = | 407.38 | nM | 6.39 |
| CHEMBL542181 | — | Ki | = | 645.65 | nM | 6.19 |
| CHEMBL545727 | — | Ki | = | 1047.13 | nM | 5.98 |