Assay Detail
Binding
CHEMBL671948
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Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N-(Iodopropenyl)-octahydrobenzo[f]- and -[g]quinolines: synthesis and adrenergic and dopaminergic activity studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.43 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL336274 | — | — | 1 | 7.10 |
| CHEMBL132304 | — | — | 1 | 6.92 |
| CHEMBL134746 | — | — | 1 | 6.66 |
| CHEMBL421914 | — | — | 1 | 6.57 |
| CHEMBL670 | TEPA | — | 1 | 6.37 |
| CHEMBL134273 | — | — | 1 | 6.16 |
| CHEMBL133615 | — | — | 1 | 5.95 |
| CHEMBL336128 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL336274 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL132304 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL134746 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL421914 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL670 | TEPA | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL134273 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL133615 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL336128 | — | IC50 | = | 1900.0 | nM | 5.72 |