Compound Detail
CHEMBL670
TEPA Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL670 |
| Name | TEPA |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FYAMXEPQQLNQDM-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
6
Publications
1
Known Names
Molecular Properties
173.2
MW (Da)
0.04
ALogP
1
HBA
0
HBD
26.1
PSA (Ų)
0.44
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(2) dopamine receptor CHEMBL339 | IC50 | 6.66 | 6.66 | 220.0 | 1 |
| D(1A) dopamine receptor CHEMBL265 | IC50 | 6.37 | 6.37 | 430.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(2) dopamine receptor | IC50 | = | 220.0 | nM | 6.66 | Inhibition of specific binding of [3H]spiroperidol to Dopamine receptor D2 in ra... | 9767652 |
| D(1A) dopamine receptor | IC50 | = | 430.0 | nM | 6.37 | Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membra... | 9767652 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 3806574 | 10.1021/jm00157a023 | Mus musculus | 6 |
| 2431142 | 10.1021/jm00161a016 | P388 | 5 |
| 2431142 | 10.1021/jm00161a016 | ADMET | 1 |
| 3806574 | 10.1021/jm00157a023 | No relevant target | 1 |
| 9767652 | 10.1021/jm980284m | D(2) dopamine receptor | 1 |
| 9767652 | 10.1021/jm980284m | D(1A) dopamine receptor | 1 |
Data from ChEMBL 36 via Core Engine