Assay Detail
Binding
CHEMBL672005
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
10-substituted 11-oxygenated (R)-aporphines: synthesis, pharmacology, and modeling of 5-HT1A receptor interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.34 | 5.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL331100 | — | — | 1 | 5.84 |
| CHEMBL324372 | — | — | 1 | 5.32 |
| CHEMBL119150 | — | — | 1 | 4.85 |
| CHEMBL119223 | — | — | 1 | - |
| CHEMBL117730 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL331100 | — | Ki | = | 1440.0 | nM | 5.84 |
| CHEMBL324372 | — | Ki | = | 4820.0 | nM | 5.32 |
| CHEMBL119150 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL119223 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL117730 | — | Ki | > | 5000.0 | nM | - |