Assay Detail
Binding
CHEMBL672018
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Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and molecular modeling of 1-phenyl-1,2,3,4-tetrahydroisoquinolines and related 5,6,8,9-tetrahydro-13bH-dibenzo[a,h]quinolizines as D1 dopamine antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.90 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | — | 1 | 9.40 |
| CHEMBL303993 | — | — | 1 | 8.18 |
| CHEMBL334350 | — | — | 1 | 8.08 |
| CHEMBL336218 | — | — | 1 | 6.86 |
| CHEMBL299056 | — | — | 1 | 6.76 |
| CHEMBL300778 | — | — | 1 | 6.75 |
| CHEMBL135318 | — | — | 1 | 6.43 |
| CHEMBL293158 | — | — | 1 | 6.36 |
| CHEMBL57988 | — | — | 1 | 6.25 |
| CHEMBL446396 | — | — | 1 | 6.13 |
| CHEMBL323771 | — | — | 1 | 6.08 |
| CHEMBL445129 | — | — | 1 | 5.57 |
| CHEMBL434809 | — | — | 1 | - |
| CHEMBL137420 | — | — | 1 | - |
| CHEMBL109723 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL303993 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL334350 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL336218 | — | Ki | = | 138.0 | nM | 6.86 |
| CHEMBL299056 | — | Ki | = | 174.0 | nM | 6.76 |
| CHEMBL300778 | — | Ki | = | 179.0 | nM | 6.75 |
| CHEMBL135318 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL293158 | — | Ki | = | 442.0 | nM | 6.36 |
| CHEMBL57988 | — | Ki | = | 565.0 | nM | 6.25 |
| CHEMBL446396 | — | Ki | = | 743.0 | nM | 6.13 |
| CHEMBL323771 | — | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL445129 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL434809 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL137420 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL109723 | — | Ki | > | 5000.0 | nM | - |